Validated screening assays for toxicity and efficacy in HTS

　•Toxicity Assays:

—Cardiotoxicity: Cardiotox Assay

—Teratogenecity: Teratox Assay

—Ototoxicity: Ototox Assay  ---- Ton 2005

—Acute Toxicity: Acutetox Assay ---- FET Guideline, OECD draft

　•Efficacy Assays:　

—Cancer: Antiangiogenic Assay

—CNS: Alzheimer ---- Acetylcholinesterase Inhibition Assay 

—Bone-Cartilage: Bone destruction-generation Assay