PHARMAKINE´S SERVICES
EFFICACY STUDIES
IN VIVO TUMOR MODELS:
•Experimental Metastasis:
—Systemic Metastasis Models
—Liver Metastasis
—Lung Metastasis
•Tumor models:
—Orthotopic Models
—Intra-Osseus Models
—Intra-Cranial Models
—Subcutaneous Models
IN VITRO CELL-BASED ASSAYS:
—Cell Toxicity
—Cell Proliferation
—Apoptosis
—Cell Adhesion
—Cell Migration
—Molecular Detection
ESPECIALIZED PRECLINICAL STUDIES:
—Drug Effect on angiogenesis Associated Mechanisms
—Drug Effect on Metastasis Implantation-Related mechanisms
—Drug Effect on Oxidative Stress-Promoted Metastasis Development
—Drug Effect on Bone Metastasis-Related Mechanisms
CYTOGENETICS
—Metaphase Karyotyping of Human Cells
—Fluorescence in situ Hybridization (FISH)
—Spectral Human Karyotypes (SKY) for Structural Genomic Aberration
—Comparative Genomic Hybridization (CGH Arrays and CGH Metaphase)
—Detection of Gene Copy Number by Real-Time PCR
—Customized Design and Validation of Probes for FISH Assays
MOLECULAR GENETICS
—RNA, DNA & Protein Quality and Quantity Analysis
—Real time PCR & RT-PCR
—DNA Sequencing
—Gene Expression DNA Microarrays
—DNA & RNA Isolation and Purification
—SNPs Analysis
—PCR Patogen Detection
—Pharmacogenomics Customized Services
HISTOLOGY
—Tissue processing
—Inmunohistochemistry / Inmmunocytochemistry
—Standard Special Staining Techniques
—Customized Tissue Array Service
—Laser Capture Microdisecction (LCM) and Image Analysis
—Studies:
—Apoptosis and Necrosis
—Angiogenesis
—Inflammation
—Hepatic Diseases
—Tissue Regeneration
—Dermatology