Curriculum Vitae: Juan Carlos Izpisúa, Ph. D.

 

Juan Carlos Izpisúa

 

MSc. (with Honors).in Pharmacology and PhD in Biochemistry and Pharmacology, with a postdoctoral fellow in the University of Marburg, Germany, and another postdoctoral fellow in the European Molecular Biology Laboratories (EMBL), Germany.

He went to The Salk Institute of California (San Diego) as assistant professor in 1993, and nowadays is a Professor in this research center, where he directs a laboratory and they are working with the zebra fish as research´s model organism.

During his professional life he has received several honors/awards like the National Science Foundation Creativity Award (1999), American Heart Association Established Investigator Award (2000), or the Medal from the Spanish College of Pharmacy (2006).

He has the responsibility of been part of the Scientific Journal Editorial Board Member er of several journals, as BMC Developmental Biology, Development, Developmental Biology, Development Genes & Evolution, Development Growth and Differentiation, International Journal of Developmental Biology and Mechanisms of Development.

Since 2004 he is the Director of the Center of Regenerative Medicine in Barcelona, and the President of the Scientific Advisory Board of Biobide.

 

 

MOST RELEVANT ARTICLES

  • Izpisúa Belmonte, J.C., Falkenstein, H., Dollé, P., Renucci, A. and Duboule, D. (1991).  Murine genes related to the Drosophila AbdB homeotic genes are sequentially expressed during development of the posterior part of the body.  EMBO J. 10:2279-2289.
  • Izpisúa Belmonte, J. C., Tickle, C., Dollé, P. and Duboule, D. (1991).  HOX-4 genes and the molecular basis of vertebrate limb pattern formation.  Seminars in Dev. Biol. 2:385-391.
  • Fjose, A., Izpisúa Belmonte, J. C., Fromental, C. and Duboule, D. (1994).  Expression of the zebrafish gene hlx-1 in the prechordal plate and during CNS development. Development 120:71-81.
  • Kanegae, Y., Tavares, A.T., Izpisúa Belmonte, J.C. and Verma, I.M. (1998).  Role of Rel/NF-B transcription factors during the outgrowth of the vertebrate limb.  Nature 392:611-614.
  • Capdevila, J., Rodriguez-Esteban, C. and Izpisúa Belmonte, J. C. (1998).  Molecular architecture of the vertebrate limb. Scientific American 12: 23-37 (Sp. edit.).
  • Yonei-Tamura, S., Tamura, K., Tsukui, T. and Izpisúa Belmonte, J.C. (1999).  Spatially and temporally-restricted expression of two T-box genes during zebrafish embryogenesis.  Mech. Dev. 80:219-221.
  • Capdevila, J. and Izpisúa Belmonte, J.C. (1999).  Extracellular modulation of the Hedgehog,Wnt and TGF signalling pathways during embryonic development. Curr. Opin. Genet. Dev. 9:427-433.
  • Tamura, K., Yonei-Tamura, S. and Izpisúa Belmonte, J.C. (1999).  Differential expression of Tbx4 and Tbx5 in Zebrafish fin buds. Mech. Dev. 87:181-184.
  • Kawakami, Y., Rodriguez-Leon, J., Koth, C.M., Büscher, D., Itoh, T., Raya, A., Ng, J.K., Rodriguez Esteban, C., Takahashi, S., Henrique, D., Schwarz, M.F., Asahara, H. and Izpisúa Belmonte, J.C. (2003).  MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb. Nature Cell Biology 5:513-519.
  • Raya, A., Koth, C.M., Büscher, D., Kawakami, Y., Itoh, T., Raya, R.M., Sternik, G., Tsai, H.-J., Rodriguez-Esteban, C. and Izpisúa Belmonte, J.C. (2003).  Activation of Notch signaling pathway precedes heart regeneration in zebrafish.  Proc. Natl. Acad. Sci. USA, Special Supplement on Stem Cells and the Future of   Regenerative Medicine.  100:11889-11895.
  • Kang, J.S., Oohashi, T., Kawakami, Y., Bekku, Y., Izpisúa Belmonte, J.C. and Ninomiya, Y. (2004).  Characterization of dermacan, a novel zebrafish lectican gene, expressed in dermal bones. Mechanisms of Development.  121(3):301-312.
  • Kawakami, Y., Tsuda, M., Takahashi, S., Taniguchi, N., Rodriguez-Esteban, C., Zemmyo, M., Furumatsu, T., Lotz, M., Izpisúa Belmonte, J.C. and Asahara, H.  (2005).  Transcriptional co-activator PGC-1 regulates chondrogenesis via association with Sox 9. PNAS. 102: 2414-2419
  • Francisco-Morcillo, J., Sanchez-Calderon, H., Kawakami, Y., Izpisua Belmonte, J.C., Hidalgo-Sanchez, M., Martin-Partido, G. (2005) Expression of Fgf19 in the developing eye. Developmental Brain Research. 156:104-109
  • Correa, R., Matsui, T., Tergaonkar, V., Rodriguez-Esteban, C., Izpisua Belmonte, J.C., Verma, I. (2005) Zebrafish IkB kinase 1 (Ikk1) negatively regulates NF-kB activity. Current Biology. 15: 1291-1295
  • Kawakami, Y., Raya, A., Raya, R.M., Rodriguez-Esteban, C., Izpisua Belmonte, J.C.  (2005). Retinoic acid signaling links left-right asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo. Nature. 435: 165-171
  • Suzuki, A., Raya, A., Kawakami, Y., Morita, M., Matsui, T., Nakashima, K., Gage, F.H., Rodriguez-Esteban, C., Izpisua Belmonte, J.C. (2006) Maintenance of embryonic stem cell pluripotency by Nanog-mediated reversal of mesoderm specification. Nature Clinical Practice Cardiovascular Medicine. 3:S114-S122
  • Matsui, T., Raya, A., Callol, C., Kawakami, Y., Oishi, I., Rodriguez-Esteban, C., and Izpisua Belmonte, J.C. (2007) Miles apart-mediated regulation of cell-Fibronectin interaction is required for proper myocardial migration in zebrafish. Nature Clinical Practice Cardiovascular Medicine. 4:S77-S82.
  • Hurle, M., Tramullas, M., Diaz, A., San-Emeterio, E.P., Morchon, N., Buscher, D., Merino, R., Hurle, J.M., and Izpisua Belmonte, J.C. (2007) Evidence for a new function of TGF signaling in the control of pain perception. Nature Neuroscience. Submitted.

 

 

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