Curriculum Vitae: Dr. Juan Carlos Izpisúa
Licenciado (con honores) en Farmacología, y Doctor en Bioquímica y Farmacología. Cuenta con dos postdoctorados, el primero realizado en la Universidad de Marburg, Alemania y el segundo en European Molecular Biology Laboratories (EMBL), Alemania.
En 1993 empezó a trabajar como profesor ayudante en el Salk Institute de California (San Diego), siendo en la actualidad profesor de este centro, donde dirige un laboratorio de gran prestigio por los trabajos realizados con el modelo animal de pez cebra (Danio rerio).
A lo largo de su vida ha recibido diversos premios por su gran trayectoria profesional como el National Science Foundation Creativity Award (1999), el American Heart Association Established Investigation Award (2000) o la Medalla del Spanish College of Pharmacy (2006).
Actualmente forma parte del Comité Científico Asesor editorial de varias revistas, como BMC Developmental Biology, Development, Developmental Biology, Development Genes & Evolution, Development Growth and Differentiation, International Journal of Developmental Biology y Mechanisms of Development.
Desde 2004 es el Director del Centro de Medicina Regenerativa de Barcelona, y el Presidente del Consejo Científico Asesor de Biobide.
PUBLICACIONES MÁS RELEVANTES
- Izpisúa Belmonte, J.C., Falkenstein, H., Dollé, P., Renucci, A. and Duboule, D. (1991). Murine genes related to the Drosophila AbdB homeotic genes are sequentially expressed during development of the posterior part of the body. EMBO J. 10:2279-2289.
- Izpisúa Belmonte, J. C., Tickle, C., Dollé, P. and Duboule, D. (1991). HOX-4 genes and the molecular basis of vertebrate limb pattern formation. Seminars in Dev. Biol. 2:385-391.
- Fjose, A., Izpisúa Belmonte, J. C., Fromental, C. and Duboule, D. (1994). Expression of the zebrafish gene hlx-1 in the prechordal plate and during CNS development. Development 120:71-81.
- Kanegae, Y., Tavares, A.T., Izpisúa Belmonte, J.C. and Verma, I.M. (1998). Role of Rel/NF-B transcription factors during the outgrowth of the vertebrate limb. Nature 392:611-614.
- Capdevila, J., Rodriguez-Esteban, C. and Izpisúa Belmonte, J. C. (1998). Molecular architecture of the vertebrate limb. Scientific American 12: 23-37 (Sp. edit.).
- Yonei-Tamura, S., Tamura, K., Tsukui, T. and Izpisúa Belmonte, J.C. (1999). Spatially and temporally-restricted expression of two T-box genes during zebrafish embryogenesis. Mech. Dev. 80:219-221.
- Capdevila, J. and Izpisúa Belmonte, J.C. (1999). Extracellular modulation of the Hedgehog,Wnt and TGF signalling pathways during embryonic development. Curr. Opin. Genet. Dev. 9:427-433.
- Tamura, K., Yonei-Tamura, S. and Izpisúa Belmonte, J.C. (1999). Differential expression of Tbx4 and Tbx5 in Zebrafish fin buds. Mech. Dev. 87:181-184.
- Kawakami, Y., Rodriguez-Leon, J., Koth, C.M., Büscher, D., Itoh, T., Raya, A., Ng, J.K., Rodriguez Esteban, C., Takahashi, S., Henrique, D., Schwarz, M.F., Asahara, H. and Izpisúa Belmonte, J.C. (2003). MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb. Nature Cell Biology 5:513-519.
- Raya, A., Koth, C.M., Büscher, D., Kawakami, Y., Itoh, T., Raya, R.M., Sternik, G., Tsai, H.-J., Rodriguez-Esteban, C. and Izpisúa Belmonte, J.C. (2003). Activation of Notch signaling pathway precedes heart regeneration in zebrafish. Proc. Natl. Acad. Sci. USA, Special Supplement on Stem Cells and the Future of Regenerative Medicine. 100:11889-11895.
- Kang, J.S., Oohashi, T., Kawakami, Y., Bekku, Y., Izpisúa Belmonte, J.C. and Ninomiya, Y. (2004). Characterization of dermacan, a novel zebrafish lectican gene, expressed in dermal bones. Mechanisms of Development. 121(3):301-312.
- Kawakami, Y., Tsuda, M., Takahashi, S., Taniguchi, N., Rodriguez-Esteban, C., Zemmyo, M., Furumatsu, T., Lotz, M., Izpisúa Belmonte, J.C. and Asahara, H. (2005). Transcriptional co-activator PGC-1 regulates chondrogenesis via association with Sox 9. PNAS. 102: 2414-2419
- Francisco-Morcillo, J., Sanchez-Calderon, H., Kawakami, Y., Izpisua Belmonte, J.C., Hidalgo-Sanchez, M., Martin-Partido, G. (2005) Expression of Fgf19 in the developing eye. Developmental Brain Research. 156:104-109
- Correa, R., Matsui, T., Tergaonkar, V., Rodriguez-Esteban, C., Izpisua Belmonte, J.C., Verma, I. (2005) Zebrafish IkB kinase 1 (Ikk1) negatively regulates NF-kB activity. Current Biology. 15: 1291-1295
- Kawakami, Y., Raya, A., Raya, R.M., Rodriguez-Esteban, C., Izpisua Belmonte, J.C. (2005). Retinoic acid signaling links left-right asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo. Nature. 435: 165-171
- Suzuki, A., Raya, A., Kawakami, Y., Morita, M., Matsui, T., Nakashima, K., Gage, F.H., Rodriguez-Esteban, C., Izpisua Belmonte, J.C. (2006) Maintenance of embryonic stem cell pluripotency by Nanog-mediated reversal of mesoderm specification. Nature Clinical Practice Cardiovascular Medicine. 3:S114-S122
- Matsui, T., Raya, A., Callol, C., Kawakami, Y., Oishi, I., Rodriguez-Esteban, C., and Izpisua Belmonte, J.C. (2007) Miles apart-mediated regulation of cell-Fibronectin interaction is required for proper myocardial migration in zebrafish. Nature Clinical Practice Cardiovascular Medicine. 4:S77-S82.
- Hurle, M., Tramullas, M., Diaz, A., San-Emeterio, E.P., Morchon, N., Buscher, D., Merino, R., Hurle, J.M., and Izpisua Belmonte, J.C. (2007) Evidence for a new function of TGF signaling in the control of pain perception. Nature Neuroscience. Submitted.